N3-Poly(L-Arginine) polymer structure

N3-Poly(L-Arginine) (N3-PArg)

Price range: $280.00 through $1,600.00

N₃-Poly(L-Arginine) (N₃-PArg) is an azide-functionalized cationic polypeptide composed of poly(L-arginine) with a terminal azide (N₃) group. The azide functionality enables efficient click chemistry with alkyne- and DBCO-containing molecules, while the poly(L-arginine) backbone contains multiple guanidinium groups that promote cellular uptake and nucleic acid complexation. N₃-PArg is widely used in click chemistry, gene delivery, nanoparticle engineering, intracellular delivery, and biomaterials research.

Product Name: N₃-Poly(L-Arginine)
Alternative Name: N₃-PArg, Azide-Poly(L-Arginine), Azide-PArg
Molecular Weight: Custom
Degree of Polymerization: Custom
Functional Groups: Terminal Azide (N₃), Multiple Guanidinium Groups
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS, aqueous buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

N3-Poly(L-Arginine) polymer structure

 

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SKU: 27800 Categories: , ,

Description

General Description

N3-Poly(L-Arginine) (N3-PArg) is a multifunctional cationic polypeptide designed for bioorthogonal conjugation and advanced drug delivery applications. The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN, enabling highly selective conjugation under mild conditions.

The poly(L-arginine) backbone contains multiple positively charged guanidinium groups that readily interact with negatively charged biomolecules, including DNA, RNA, siRNA, and mRNA. Poly(L-arginine) is also recognized as an efficient cell-penetrating polymer, facilitating intracellular delivery of nucleic acids, proteins, peptides, and therapeutic agents.

The combination of a terminal azide group and a biodegradable poly(L-arginine) backbone makes N₃-PArg an excellent material for gene delivery, click chemistry, polymer-drug conjugates, nanoparticle functionalization, molecular imaging, and advanced biomaterials research.

Applications

  • Click chemistry (CuAAC)
  • Copper-free click chemistry (SPAAC)
  • Gene delivery
  • DNA and RNA complexation
  • Protein and peptide delivery
  • Nanoparticle functionalization
  • Surface modification
  • Molecular imaging
  • Drug delivery systems
  • Biomaterials research

Features and Benefits

  • Terminal azide functionality
  • Compatible with CuAAC click chemistry
  • Compatible with SPAAC chemistry
  • Multiple guanidinium groups
  • Excellent cellular uptake
  • Strong nucleic acid binding
  • Biodegradable polypeptide

Additional information

Package Size

50mg, 100mg, 200mg, 500mg, 1g

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