Description
General Description
OPSS-Poly(L-Arginine) is a functional cationic polypeptide designed for reversible thiol conjugation and advanced drug delivery applications. The terminal OPSS (ortho-pyridyl disulfide) group reacts rapidly and selectively with free sulfhydryl (thiol) groups on proteins, peptides, antibodies, and other biomolecules through thiol-disulfide exchange, forming cleavable disulfide linkages while releasing pyridine-2-thione.
The poly(L-arginine) backbone contains multiple positively charged guanidinium groups that readily interact with negatively charged nucleic acids such as DNA, RNA, siRNA, and mRNA. Poly(L-arginine) is also well known for its excellent cell-penetrating properties, making it an attractive carrier for intracellular delivery of nucleic acids, proteins, peptides, and small molecules.
The combination of a cationic biodegradable polypeptide and a terminal OPSS group makes OPSS-PArg an excellent material for redox-responsive drug delivery, reversible protein conjugation, gene delivery, nanoparticle functionalization, hydrogel preparation, and advanced biomaterials.
Applications
- Reversible thiol conjugation
- Gene delivery
- DNA and RNA complexation
- Protein and peptide delivery
- Nanoparticle functionalization
- Surface modification
- Hydrogel synthesis
- Redox-responsive drug delivery
- Cell-penetrating delivery systems
- Biomaterials research
Features and Benefits
- Terminal OPSS functionality
- Selective thiol-disulfide exchange
- Forms cleavable disulfide linkages
- Multiple guanidinium groups
- Excellent cellular uptake
- Strong nucleic acid binding
- Biodegradable polypeptide
- Available in multiple molecular weights
