poly(L-Arginine) chemical structure

Poly(L-Arginine)/poly(L-Arg)

Price range: $360.00 through $1,600.00

Poly(L-Arginine) (PLAr) is a cationic polypeptide composed of repeating L-arginine residues. Due to its high density of positively charged guanidinium groups, Poly(L-Arginine) exhibits strong interactions with nucleic acids, proteins, cell membranes, and negatively charged biomaterials. It is widely used in gene delivery, cell culture, nanoparticle formulation, surface coating, tissue engineering, and biomedical research.

Product Name: Poly(L-Arginine)
Alternative Name: PLArg, Polyarginine
Polymer Type: Cationic Polypeptide
Molecular Weight: 5k, 10k, 15k, 30k, 50k, 70k Da, Custom
Monomer: L-Arginine
Counter Ion: Acetate, Hydrochloride, TFA, Custom
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS, Saline
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

poly(L-Arginine) chemical structure

 

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Technical Data

Chemical name: poly(L-arginine hydrochloride)

CAS number:     26982-20-7

Appearance (color)  White to faint yellow

Polymerization degree            Molecular Weight (Da)

n=10                                               1,900

n=20                                               3,800     

n=30                                               5,800

n=50                                               9,500  

n=100                                              19K

n=200                                              38K

 

Description

General Description

Poly(L-Arginine) is a synthetic polyamino acid derived from the amino acid L-arginine. The polymer contains guanidinium-functional side chains that remain positively charged under physiological conditions, providing strong electrostatic interactions with negatively charged molecules and biological surfaces.

Compared with poly(L-lysine), Poly(L-Arginine) often exhibits enhanced cellular uptake due to the unique membrane-translocating properties of guanidinium groups. This characteristic makes Poly(L-Arginine) particularly attractive for gene delivery, intracellular transport, cell-penetrating systems, and nanomedicine applications.

Poly(L-Arginine) is frequently utilized for DNA and RNA complexation, nanoparticle surface modification, tissue engineering scaffolds, cell adhesion studies, antimicrobial coatings, and biomaterials development.

Applications

  • Gene delivery
  • DNA complexation
  • RNA delivery
  • Nanoparticle formulation
  • Cell culture surface coating
  • Cell adhesion studies
  • Tissue engineering
  • Drug delivery systems
  • Biomaterials development
  • Biomedical research

Features and Benefits

  • Highly cationic polypeptide
  • Guanidinium-rich structure
  • Strong nucleic acid binding capability
  • Enhanced cellular uptake properties
  • Excellent water solubility
  • Biocompatible amino acid-based polymer
  • Suitable for nanoparticle formulation
  • Useful for surface modification
  • Available in multiple molecular weights

Additional information

Molecular Weight

1900, 3800, 5800, 9500, 19K, 38K
Package Size

100mg, 200mg, 500mg, 1g

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