PEI-g-PEG-N3

PEI-g-PEG-N3

Price range: $460.00 through $480.00

PEI-g-PEG-N3 is a graft copolymer consisting of polyethylenimine (PEI) modified with polyethylene glycol (PEG) chains terminated with azide (N3) groups. The PEI backbone provides efficient nucleic acid complexation, while PEG improves biocompatibility and colloidal stability. The terminal azide functionality enables highly selective click chemistry conjugation with alkyne- and DBCO-containing molecules. PEI-g-PEG-N3 is widely used in gene delivery, nanoparticle engineering, targeted drug delivery, and biomaterials research.

Product Name: PEI-g-PEG-N3
Full Name: Polyethylenimine-graft-Polyethylene Glycol Azide
PEI Molecular Weight: 800 Da, 1.8k, 2k, 10k, 25k, Custom
PEG Molecular Weight: 550, 1000, 2000, 3400, 5000 Da, Custom
PEG Substitution: Customizable
Functional Groups: PEI, PEG, Azide (N3)
Appearance: White to off-white solid or lyophilized powder
Solubility: Water, PBS, DMSO
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

  • Specified molecular weight of PEI  and PEG:PEI ratio may be offered by custom synthesis. Please contact us for quotation.
Request Bulk Quote? Request Custom Synthesis?
SKU: 12166 Categories: , ,

Description

General Description

PEI-g-PEG-N3 combines the strong nucleic acid binding capability of PEI with the stealth and biocompatibility benefits of PEG. The cationic PEI backbone efficiently complexes DNA, mRNA, siRNA, plasmids, oligonucleotides, and CRISPR components through electrostatic interactions.

PEG grafting reduces the cytotoxicity typically associated with PEI, improves aqueous solubility, minimizes aggregation, and enhances colloidal stability. The terminal azide groups provide a versatile platform for bioorthogonal conjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC).

PEI-g-PEG-N3 is commonly used for targeted gene delivery systems, nanoparticle surface engineering, antibody conjugation, peptide conjugation, molecular imaging, and advanced nanomedicine applications.

Applications

  • Gene delivery
  • DNA transfection
  • mRNA delivery
  • siRNA delivery
  • CRISPR delivery
  • Click chemistry conjugation
  • Nanoparticle functionalization
  • Antibody conjugation
  • Targeted drug delivery
  • Biomaterials research

Features and Benefits

  • Efficient nucleic acid complexation
  • Reduced PEI-associated cytotoxicity
  • Improved aqueous solubility
  • Enhanced colloidal stability
  • Reactive azide functionality
  • Compatible with CuAAC and SPAAC chemistry
  • Suitable for nanoparticle engineering
  • Excellent surface modification capability
  • Available in multiple PEI and PEG molecular weights

Additional information

PEI Molecular Weight

10K, 25K
PEG molecular Weight

2000, 5000
PEG:PEI Ratio

10%, 20%
Package size

50mg, 100mg

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