(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide (TFA-L-Lys NCA)

Description

General Description

(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide (TFA-L-Lys NCA) is the N-carboxyanhydride derivative of N6-trifluoroacetyl-L-lysine. The trifluoroacetyl group effectively protects the lysine side-chain amine during polymerization, allowing controlled synthesis of poly(N6-trifluoroacetyl-L-lysine) and related copolymers through ring-opening polymerization techniques.

Following polymerization, the trifluoroacetyl protecting groups can be removed under appropriate conditions to generate poly(L-lysine) with pendant primary amine functionalities. These amine groups provide versatile reactive sites for conjugation with PEG, peptides, proteins, drugs, fluorophores, targeting ligands, and other biomolecules. N6-Trifluoroacetyl-L-lysine NCA is widely used in the preparation of functional polypeptides, gene delivery materials, nanomedicine platforms, and advanced biomaterials.

Applications

• Poly(L-lysine) synthesis
• Ring-opening polymerization
• Polypeptide synthesis
• Gene delivery materials
• Drug delivery systems
• PEGylated polypeptides
• Nanoparticle preparation
• Biomaterials development
• Tissue engineering
• Polymer conjugation

Features and Benefits

• Protected lysine NCA monomer
• Efficient ring-opening polymerization
• Trifluoroacetyl-protected ε-amine
• Enables synthesis of functional polypeptides
• Controlled polymerization behavior
• Deprotection yields reactive primary amines
• Suitable for block copolymer synthesis
• Excellent versatility in biomaterials research
• Useful precursor for poly(L-lysine)-based polymers