Description
General Description
Stearic Acid-PEG-NHS is a heterobifunctional lipid-PEG derivative composed of a hydrophobic stearic acid (C18) lipid, a hydrophilic polyethylene glycol (PEG) spacer, and a terminal N-hydroxysuccinimide (NHS) ester. The stearic acid moiety readily incorporates into lipid bilayers, liposomes, micelles, and other lipid-based nanocarriers, while the PEG chain enhances aqueous solubility, steric stabilization, and biocompatibility.
The terminal NHS ester reacts efficiently with primary amines under mild aqueous conditions (typically pH 7.2–8.5), allowing covalent attachment of peptides, proteins, antibodies, enzymes, aptamers, and other amine-containing ligands through stable amide bonds.
Stearic Acid-PEG-NHS is extensively used for preparing functional liposomes, lipid nanoparticles (LNPs), targeted drug delivery systems, diagnostic probes, biosensors, and other advanced nanomedicine platforms.
Applications
- Liposome surface modification
- Lipid nanoparticle (LNP) functionalization
- Protein conjugation
- Peptide conjugation
- Antibody conjugation
- Targeted drug delivery
- Nanoparticle surface engineering
- Biomolecule immobilization
- Molecular imaging
- Biomaterials research
Features and Benefits
- Hydrophobic stearic acid anchor
- Hydrophilic PEG spacer
- Terminal NHS ester for amine coupling
- Rapid and efficient conjugation under mild conditions
- Stable amide bond formation
- Excellent aqueous dispersibility
- Outstanding biocompatibility
- Research-grade quality
